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sodium monofluorophosphate

A01AA02

Forms & Strengths

Toothpaste: 0.76% to 1.14% w/w
Oral rinse/solution: 0.05% to 0.4% w/w
Topical gel: 1.1% w/w

Adult Dosing

Dental caries prevention: Apply a ribbon of toothpaste containing 0.76% sodium monofluorophosphate to toothbrush and brush thoroughly for at least 2 minutes at least twice daily.
Oral rinse: Swish 10 mL of 0.05% solution vigorously around teeth for 1 minute, then spit out, once or twice daily after brushing.

Pediatric Dosing

Children 6 years and older: Same as adult dosing; use a pea-sized amount of toothpaste and supervise to minimize swallowing.
Children 2 to 5 years: Use a smear-sized amount (rice grain) of toothpaste under adult supervision twice daily to reduce fluorosis risk.
Children under 2 years: Consult a dentist or physician before use.

Indications

Prevention of dental caries
Reduction of dental hypersensitivity

Mechanism of Action

Dissociates in the oral cavity to release fluoride ions, which integrate into dental enamel to form fluorapatite.
Increases enamel resistance to acid dissolution by oral bacteria.
Promotes remineralization of early carious lesions and exhibits mild antibacterial effects on dental plaque.

Contraindications

Hypersensitivity to sodium monofluorophosphate or any component of the formulation
Systemic use in areas with high natural fluoride content in drinking water exceeding optimal levels (greater than 1 ppm)

Adverse Reactions

Dental fluorosis (in children under 8 years chronically ingesting excessive amounts during tooth development)
Oral mucosal irritation or contact stomatitis (rare)
Nausea and gastrointestinal upset (if large quantities are swallowed)

Drug Interactions

Concomitant ingestion of systemic fluoride supplements (drops, tablets) may increase the risk of dental fluorosis.
Frequent concurrent use of other high-concentration topical fluoride products without professional guidance.

Curated Content: Needs Vetting Before Put to Clinical Use