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ALIMENTARY TRACT AND METABOLISM › STOMATOLOGICAL PREPARATIONS › STOMATOLOGICAL PREPARATIONS › Caries prophylactic agents
combinations
A01AA30
Forms & Strengths
- Toothpaste: Sodium fluoride 0.24% / Sodium monofluorophosphate 0.76%
- Mouthwash: Sodium fluoride 0.05% / Cetylpyridinium chloride 0.05%
- Topical Gel: Acidulated phosphate fluoride 1.23% / Sodium fluoride 0.9%
Adult Dosing
- Toothpaste: Brush teeth thoroughly for at least 2 minutes, preferably after each meal or at least twice daily.
- Mouthwash: Rinse with 10 mL of solution for 1 minute, then spit out. Use once or twice daily after brushing.
- Topical Gel/Foam: Apply to teeth via tray for 1 to 4 minutes as directed by dental professional, up to 2-4 times per year.
Pediatric Dosing
- Children 6 years and older: Same as adult dosing for mouthwash and toothpaste, supervise to minimize swallowing.
- Children 2 to 6 years: Use a pea-sized amount of toothpaste; supervise brushing to minimize swallowing.
- Children under 2 years: Consult a dentist or physician before use.
Indications
- Prevention of dental caries
- Reduction of dental plaque and gingivitis (for formulations containing antimicrobial agents)
- Remineralization of early enamel carious lesions
Mechanism of Action
- Fluoride ions substitute for hydroxyl ions in hydroxyapatite to form fluorapatite, which is less soluble in acid and more resistant to decay.
- Promotes remineralization of demineralized enamel.
- Antimicrobial agents (e.g., cetylpyridinium chloride) reduce plaque-forming bacterial load and gingival inflammation.
Contraindications
- Hypersensitivity to fluoride or any component of the formulation
- Use in areas where drinking water is optimally fluoridated at high concentrations without medical/dental consultation (risk of fluorosis)
- Do not swallow (for topical oral rinses and gels)
Adverse Reactions
- Dental fluorosis (chronic ingestion in children during tooth development)
- Staining of teeth or tongue (with prolonged use of certain antimicrobial rinses)
- Oral mucosal irritation or burning sensation
- Nausea or gastrointestinal upset if swallowed in large quantities
Drug Interactions
- Minimally absorbed systemically; few significant systemic drug interactions.
- Concurrent ingestion of high doses of calcium, magnesium, or aluminum salts may bind fluoride in the GI tract, reducing local bioavailability.
Curated Content: Needs Vetting Before Put to Clinical Use