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ALIMENTARY TRACT AND METABOLISM › STOMATOLOGICAL PREPARATIONS › STOMATOLOGICAL PREPARATIONS › Antiinfectives and antiseptics for local oral treatment
natamycin
A01AB10
Adult Dosing
- Fungal keratitis: 1 drop in the conjunctival sac every 1 to 2 hours initially, gradually reduced to 1 drop 6 to 8 times daily as infection subsides
- Duration of therapy typically 14 to 21 days
Pediatric Dosing
- Fungal keratitis (Children ≥ 2 years): Same as adult dosage regimen
- Safety and efficacy in pediatric patients under 2 years not established
Indications
- Treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani
Mechanism of Action
- Polyene macrolide antimycotic that binds to sterols (primarily ergosterol) in the fungal cell membrane, altering membrane permeability and causing intracellular leakage
Contraindications
- Hypersensitivity to natamycin or any components of the formulation
Adverse Reactions
- Eye irritation
- Eye pain
- Blurred vision
- Hyperemia
- Foreign body sensation
- Allergic conjunctivitis
Drug Interactions
- No significant systemic drug interactions identified due to minimal systemic absorption following ophthalmic administration
- Concomitant use with other topical ophthalmic medications should be separated by at least 5 to 10 minutes
Curated Content: Needs Vetting Before Put to Clinical Use