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ALIMENTARY TRACT AND METABOLISM › STOMATOLOGICAL PREPARATIONS › STOMATOLOGICAL PREPARATIONS › Antiinfectives and antiseptics for local oral treatment
benzoxonium chloride
A01AB14
Forms & Strengths
- Oromucosal spray: 0.2 mg/mL
- Lozenges: 1 mg
Adult Dosing
- Oromucosal spray: 4 sprays to the affected area 3 to 6 times daily
- Lozenges: 1 lozenge dissolved slowly in the mouth every 2 to 3 hours as needed, maximum 6 lozenges daily
Pediatric Dosing
- Not recommended for children under 4 years of age
- Children over 4 years: Consult physician or follow age-appropriate reduced dosing guidelines for lozenges/spray
Indications
- Local treatment of mild infections of the mouth and throat
- Pharyngitis
- Gingivitis
- Stomatitis
- Adjunctive oral hygiene before and after dental procedures
Mechanism of Action
- Quaternary ammonium antiseptic compound acting as a cationic surfactant
- Interferes with the permeability of bacterial and fungal cell membranes, leading to cell lysis and death
- Exhibits antibacterial activity against gram-positive and gram-certain gram-negative organisms, as well as antifungal properties
Contraindications
- Hypersensitivity to benzoxonium chloride or other quaternary ammonium compounds
- Children under 4 years of age due to risk of choking and lack of controlled safety data
Adverse Reactions
- Transient local irritation in the oral cavity
- Allergic contact dermatitis
- Burning sensation or dryness of the mouth
- Rare hypersensitivity reactions including rash and pruritus
Drug Interactions
- No clinically significant systemic drug interactions reported due to minimal systemic absorption
- May be inactivated by anionic surfactants such as sodium lauryl sulfate found in some toothpastes
Curated Content: Needs Vetting Before Put to Clinical Use