← Search & browse all drugs
ALIMENTARY TRACT AND METABOLISM › STOMATOLOGICAL PREPARATIONS › STOMATOLOGICAL PREPARATIONS › Antiinfectives and antiseptics for local oral treatment
sodium perborate
A01AB19
Forms & Strengths
- Oral powder for solution: 955 mg per packet (releases hydrogen peroxide)
- Periodontal gel / Mouthwash preparations
Adult Dosing
- Dissolve contents of one packet (approx. 1 g) in a small glass of warm water (approx. 15 mL)
- Rinse or gargle for 2 minutes up to 4 times daily for acute oral infections or aphthous ulcers
Pediatric Dosing
- Children under 6 years: Safety and efficacy not established
- Children 6 years and older: Same as adult dosing, under adult supervision to prevent swallowing
Indications
- Adjunctive treatment of acute gingivitis
- Stomatitis and pharyngitis
- Aphthous ulcers and minor mouth irritations
Mechanism of Action
- Releases nascent oxygen upon contact with saliva or water
- Provides mechanical cleansing through effervescence
- Exerts mild antiseptic and antibacterial action via oxidation
Contraindications
- Hypersensitivity to sodium perborate or borate compounds
- Children under 6 years of age due to risk of accidental ingestion and boron toxicity
- Deep periodontal pockets where drainage is impaired
Adverse Reactions
- Local irritation or burning sensation of the oral mucosa
- Mild soft tissue irritation with prolonged or excessive use
- Systemic toxicity (boron poisoning) if ingested in large quantities
Drug Interactions
- None significant reported with topical oral rinses
- Avoid concurrent use of other oxidizing oral antiseptics to prevent excessive mucosal irritation
Curated Content: Needs Vetting Before Put to Clinical Use