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ALIMENTARY TRACT AND METABOLISM › STOMATOLOGICAL PREPARATIONS › STOMATOLOGICAL PREPARATIONS › Antiinfectives and antiseptics for local oral treatment
chlortetracycline
A01AB21
Forms & Strengths
- Ophthalmic Ointment: 1%
- Topical Ointment: 3%
Adult Dosing
- Ophthalmic: Apply a small amount (approx. 1 cm ribbon) to the conjunctival sac 2 to 4 times daily.
- Topical: Apply a small amount to the affected area 1 to 4 times daily.
Pediatric Dosing
- Ophthalmic (Neonates/Pediatrics): Apply to conjunctival sac 2 to 4 times daily.
- Topical (Pediatrics): Apply sparingly to affected area 1 to 4 times daily.
Indications
- Treatment of superficial ocular infections involving the conjunctiva and/or cornea caused by susceptible organisms
- Topical treatment of superficial skin infections
Mechanism of Action
- Binds reversibly to the 30S ribosomal subunit of susceptible bacteria
- Blocks the access of aminoacyl-tRNA to the mRNA-ribosome complex
- Inhibits bacterial protein synthesis and cell growth
- Bacteriostatic activity
Contraindications
- Hypersensitivity to chlortetracycline or any tetracycline class antibiotic
- Fungal or viral infections of the skin or eye
Adverse Reactions
- Local irritation
- Burning or stinging upon application
- Pruritus
- Hypersensitivity reactions including contact dermatitis
- Superimposed fungal or bacterial infections with prolonged use
Drug Interactions
- Minimally absorbed systemically via topical/ophthalmic routes, minimizing significant systemic drug interactions
- Potential antagonism with bactericidal antibiotics (e.g., penicillins) if used concomitantly on the same site
Curated Content: Needs Vetting Before Put to Clinical Use