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octenidine

A01AB24

Forms & Strengths

Solution: 0.1%
Wound Gel: 0.1%
Mouthwash: 0.1%

Adult Dosing

Topical Antiseptic (Skin/Wound): Apply undiluted to the affected area using a swab; allow minimum 1-2 minutes contact time.
Oral Mucosa: Rinse mouth with 10 mL of 0.1% solution for 30 seconds, up to 3 times daily.

Pediatric Dosing

Neonates and Infants: Safe for use, including premature infants, for skin and mucous membrane antisepsis (use with caution to prevent pooling).
Children (>0 years): Same as adult topical or oral dosing adjusted by surface area/age.

Indications

Antiseptic treatment of superficial wounds, burns, and chronic ulcers
Short-term adjunctive antimicrobial therapy in the oral cavity (e.g., gingivitis, stomatitis)
Pre-operative skin and mucous membrane disinfection

Mechanism of Action

Cationic surfactant that binds to the cell walls and membranes of microorganisms.
Alters cell membrane permeability leading to leakage of intracellular components, resulting in broad-spectrum bactericidal, fungicidal, and virucidal activity.

Contraindications

Hypersensitivity to octenidine or excipients
Application into the abdominal cavity (e.g., via lavages) or deep intra-tissue injection due to risk of severe tissue necrosis or sterile peritonitis
Use on the tympanic membrane (risk of inner ear damage)

Adverse Reactions

Transient burning, stinging, or warmth upon application to open wounds
Bitter taste (with oral rinse formulations)
Rare contact dermatitis or allergic hypersensitivity reactions

Drug Interactions

Avoid concurrent use with iodine-based antiseptics to prevent severe brownish/purple discoloration and irritation.
Avoid contact with anionic surfactants (e.g., soaps), which may precipitate and inactivate octenidine.

Curated Content: Needs Vetting Before Put to Clinical Use