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ALIMENTARY TRACT AND METABOLISM › STOMATOLOGICAL PREPARATIONS › STOMATOLOGICAL PREPARATIONS › Other agents for local oral treatment
becaplermin
A01AD08
Forms & Strengths
- Gel: 0.01% (100 mcg/g in a sodium carboxymethylcellulose aqueous base)
Adult Dosing
- Apply a thin layer of gel once daily using a clean application method (e.g., cotton swab) to cover the entire ulcerated area
- Gently cover the treated ulcer with a moist saline dressing for approximately 12 hours, then remove, rinse, and cover with a fresh moist dressing for the remaining 12 hours
- Continue treatment until complete healing of the ulcer is achieved, generally not to exceed 20 weeks
Pediatric Dosing
- Safety and effectiveness in pediatric patients below the age of 16 years have not been established
Indications
- Treatment of lower extremity diabetic neuropathic ulcers that extend down to subcutaneous tissue or beyond and have an adequate blood supply
Mechanism of Action
- Recombinant human platelet-derived growth factor (rhPDGF-BB)
- Promotes chemotactic recruitment and proliferation of cells involved in wound repair
- Enhances granulation tissue formation, collagen synthesis, and overall wound healing
Contraindications
- Known hypersensitivity to platelet-derived growth factor or any component of the gel
- Presence of known neoplasm(s) at the site of application
Adverse Reactions
- Erythema
- Rash
- Burning sensation at the application site
- Skin irritation
- Increased incidence of mortality secondary to malignancy has been observed in patients using 3 or more tubes (boxed warning)
Drug Interactions
- No formal drug-drug interaction studies have been conducted with becaplermin gel
- Avoid concurrent application of other topical medications or agents at the ulcer site to prevent altered drug absorption or efficacy
Curated Content: Needs Vetting Before Put to Clinical Use