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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR ACID RELATED DISORDERS › ANTACIDS › Magnesium compounds
combinations
A02AA10
Forms & Strengths
- Tablets: 20mg/5mg
- Capsules: 20mg/5mg
- Injectable: 40mg/10mg/mL
Adult Dosing
- 20-40mg/5-10mg PO daily
- 40mg/10mg IV/IM daily
- Dosage adjustments for renal impairment
Pediatric Dosing
- Not established for children under 18
- Consult pediatric specialist for guidance
Indications
- Treatment of gastroesophageal reflux disease (GERD)
- Healing of erosive esophagitis
- Zollinger-Ellison syndrome
Mechanism of Action
- Omeprazole inhibits H+/K+ ATPase
- Reducing gastric acid secretion
- Pantoprazole has similar mechanism
Contraindications
- Hypersensitivity to components
- Concomitant use with atazanavir
- Concomitant use with nelfinavir
Adverse Reactions
- Headache
- Diarrhea
- Abdominal pain
- Flatulence
- Vitamin B12 deficiency with long-term use
Drug Interactions
- Warfarin: increased INR
- Diazepam: increased sedation
- Phenytoin: decreased phenytoin levels
- Clopidogrel: decreased platelet aggregation
Curated Content: Needs Vetting Before Put to Clinical Use