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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR ACID RELATED DISORDERS › ANTACIDS › Aluminium compounds
aluminium glycinate
A02AB07
Forms & Strengths
- Tablet, chewable: 500 mg
- Oral suspension: 500 mg/5 mL
Adult Dosing
- Peptic ulcer disease or GERD: 500 mg to 1 g orally 4 times daily, typically 1 to 3 hours after meals and at bedtime
- Max daily dose: 8 g/day
Pediatric Dosing
- Safety and efficacy not well established in pediatric patients
- If used for hyperacidity: 250 mg to 500 mg orally 4 times daily as directed by a physician
Indications
- Relief of symptoms associated with gastric hyperacidity
- Peptic ulcer disease
- Gastroesophageal reflux disease (GERD)
- Gastritis
Mechanism of Action
- Acts as an antacid by neutralizing hydrochloric acid in the stomach
- Raises gastric pH, thereby reducing pepsin activity
- Provides a demulcent and protective effect on the gastric mucosa
Contraindications
- Hypersensitivity to aluminum or any component of the formulation
- Severe renal impairment or failure (risk of aluminum accumulation and toxicity)
- Hypophosphatemia (due to aluminum binding to dietary phosphate)
Adverse Reactions
- Constipation
- Hypophosphatemia (with prolonged use or high doses)
- Aluminum toxicity, encephalopathy, and osteomalacia (in chronic renal failure)
- Nausea and abdominal discomfort
Drug Interactions
- Decreases absorption of acidic drugs such as ketoconazole, itraconazole, and iron supplements
- Decreases bioavailability of tetracyclines and fluoroquinolones through chelation (separate administration by at least 2 hours)
- May alter the urinary excretion of salicylates by alkalinizing the urine
Curated Content: Needs Vetting Before Put to Clinical Use