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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR ACID RELATED DISORDERS › ANTACIDS › Calcium compounds
calcium carbonate
A02AC01
Forms & Strengths
- Chewable tablets: 500mg, 750mg, 1000mg
- Oral suspension: 1250mg/5mL
- Calcium carbonate capsules: 500mg, 650mg
- OTC antacids: various strengths
Adult Dosing
- Dyspepsia: 500-1000mg as needed
- Hyperphosphatemia: 1-2 grams with meals
- Osteoporosis prevention: 500-2000mg/day
- Hypocalcemia: 1-2 grams/day in divided doses
Pediatric Dosing
- Neonatal hypocalcemia: 500-1500mg/kg/day
- Childhood hypocalcemia: 45-65mg/kg/day
- Adolescent osteoporosis prevention: 1300mg/day
Indications
- Dyspepsia
- Hyperphosphatemia in chronic kidney disease
- Hypocalcemia
- Osteoporosis prevention
- Gastroesophageal reflux disease (GERD)
Mechanism of Action
- Increases gastric pH by neutralizing stomach acid
- Binds to phosphate in the GI tract, reducing absorption
- Essential for bone mineralization and density
Contraindications
- Hypercalcemia
- Severe hyperphosphatemia
- Familial hypocalciuric hypercalcemia
- Kidney stones, especially calcium stones
Adverse Reactions
- Milk-alkali syndrome
- Gastrointestinal upset, constipation
- Hypercalcemia, kidney stones
- Interference with iron absorption
Drug Interactions
- Tetracyclines, bisphosphonates: reduced absorption
- Iron supplements: decreased iron absorption
- Thyroid hormones: altered thyroid hormone absorption
- Phosphate binders: additive effect
Curated Content: Needs Vetting Before Put to Clinical Use