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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR ACID RELATED DISORDERS › ANTACIDS › Combinations and complexes of aluminium, calcium and magnesium compounds
ordinary salt combinations
A02AD01
Forms & Strengths
- Tablet: 500mg/20mg
- Capsule: 250mg/10mg
- Oral liquid: 200mg/8mg/5ml
Adult Dosing
- 20-40 mg PO once daily for heartburn
- 40-80 mg PO twice daily for acid reflux
- Maximum dose: 80mg twice daily
Pediatric Dosing
- 1-2 mg/kg PO once daily for heartburn (12-17 years)
- 0.5-1 mg/kg PO once daily for heartburn (6-11 years)
- Not recommended under 6 years
Indications
- Gastroesophageal reflux disease (GERD)
- Zollinger-Ellison syndrome
- Peptic ulcers
- Erosive esophagitis
Mechanism of Action
- Proton pump inhibitor (PPI)
- Decreases gastric acid secretion by inhibiting H+/K+ ATPase
- Increases gastric pH
Contraindications
- Hypersensitivity to the active substance
- Concomitant use with atazanavir or nelfinavir
Adverse Reactions
- Headache
- Diarrhea
- Nausea
- Abdominal pain
- Vitamin B12 deficiency with long-term use
Drug Interactions
- Atazanavir, nelfinavir: decreased antiretroviral efficacy
- Warfarin: increased INR and bleeding risk
- Ketoconazole, itraconazole: decreased antifungal efficacy
- Methotrexate: increased toxicity
Curated Content: Needs Vetting Before Put to Clinical Use