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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR ACID RELATED DISORDERS › ANTACIDS › Combinations and complexes of aluminium, calcium and magnesium compounds
almasilate
A02AD05
Forms & Strengths
- Oral suspension: 500 mg/5 mL
- Chewable tablets: 500 mg
Adult Dosing
- 1 to 2 tablets or 5 to 10 mL of suspension 4 times daily
- Administer 30 to 60 minutes after meals and at bedtime, or as needed for symptom relief
- Maximum daily dose: according to local product labeling, typically not to exceed 8 doses/day
Pediatric Dosing
- Safety and efficacy in pediatric patients under 12 years are not well established
- Use in children is generally discouraged unless directed by a physician
Indications
- Symptomatic relief of hyperacidity-related conditions
- Gastritis
- Peptic ulcer disease
- Gastroesophageal reflux disease (GERD)
- Heartburn and dyspepsia
Mechanism of Action
- Non-systemic antacid containing aluminum and magnesium silicates
- Neutralizes hydrochloric acid in the stomach
- Buffers gastric pH, reducing pepsin activity
- Provides a protective coating on the gastric mucosa
Contraindications
- Hypersensitivity to aluminum or magnesium compounds
- Severe renal impairment (risk of aluminum and magnesium accumulation)
- Hypophosphatemia
- Intestinal obstruction
Adverse Reactions
- Constipation (due to aluminum content)
- Diarrhea (due to magnesium content)
- Nausea
- Abdominal discomfort
- Hypermagnesemia or aluminum toxicity in patients with renal failure with chronic use
Drug Interactions
- May decrease the absorption of concurrently administered oral medications by chelation or increasing gastric pH
- Reduces absorption of iron salts, tetracyclines, fluoroquinolones, ketoconazole, and digoxin
- Separate administration of almasilate and other oral drugs by at least 2 hours
Curated Content: Needs Vetting Before Put to Clinical Use