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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR ACID RELATED DISORDERS › DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) › Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
methiosulfonium chloride
A02BX04
Forms & Strengths
- Oral tablets: 50 mg
- Combination formulations with antacids or digestive enzymes
Adult Dosing
- Gastritis and peptic ulcer disease: 50 mg to 100 mg orally 3 times daily after meals
- Maximum daily dose: 300 mg
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
- Use generally not recommended in children
Indications
- Adjuvant treatment of gastritis
- Relief of hyperacidity symptoms and peptic ulcer disease
Mechanism of Action
- Exerts cytoprotective and anti-ulcerogenic effects on the gastric mucosa
- Acts as a methyl donor, potentially supporting mucosal tissue repair and mucin synthesis
Contraindications
- Hypersensitivity to methiosulfonium chloride or any component of the formulation
- Severe renal impairment
- Severe hepatic impairment
Adverse Reactions
- Mild gastrointestinal distress
- Nausea
- Diarrhea or abdominal discomfort
- Allergic skin rashes in sensitive individuals
Drug Interactions
- Antacids may decrease absorption if administered simultaneously
- No major cytochrome P450-mediated drug interactions well-documented due to local gastrointestinal action
Curated Content: Needs Vetting Before Put to Clinical Use