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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR ACID RELATED DISORDERS › DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) › Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
proglumide
A02BX06
Adult Dosing
- 400 mg orally three times daily, typically administered 20 minutes before meals
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Peptic ulcer disease
- Gastritis
- Hypersecretory states
Mechanism of Action
- Specific cholecystokinin (CCK-1 and CCK-2) receptor antagonist
- Competitively blocks gastrin at the CCK-2/gastrin receptors on gastric parietal cells
- Inhibits gastric acid secretion and pepsin output
Contraindications
- Hypersensitivity to proglumide or any component of the formulation
- Active upper gastrointestinal hemorrhage
- Known or suspected malignant gastric ulceration
Adverse Reactions
- Nausea
- Constipation
- Headache
- Dizziness
- Dry mouth
- Mild gastrointestinal distress
Drug Interactions
- Antacids may decrease the absorption and efficacy of proglumide
- Concomitant anticholinergic agents may antagonize the antisecretory effects
- May alter the absorption of concomitantly administered drugs sensitive to gastric pH changes
Curated Content: Needs Vetting Before Put to Clinical Use