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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR ACID RELATED DISORDERS › DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) › Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
acetoxolone
A02BX09
Forms & Strengths
- 100 mg tablet
- 200 mg capsule
- 250 mg/5 mL oral solution
Adult Dosing
- 100-200 mg orally three times daily
- Maximum dose: 600 mg/day
Pediatric Dosing
- Not established for pediatric patients
- Use with caution in patients under 18 years old
Indications
- Treatment of peptic ulcer disease
- Gastroesophageal reflux disease (GERD)
- Zollinger-Ellison syndrome
Mechanism of Action
- Inhibits gastric acid secretion
- Antisecretory effect on gastric mucosa
Contraindications
- Hypersensitivity to acetoxolone
- Severe liver disease
- Severe kidney disease
Adverse Reactions
- Headache
- Dizziness
- Diarrhea
- Abdominal pain
- Nausea and vomiting
Drug Interactions
- Antacids: decreased absorption
- Theophylline: increased theophylline levels
- Warfarin: increased warfarin levels
Curated Content: Needs Vetting Before Put to Clinical Use