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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR ACID RELATED DISORDERS › DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) › Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
troxipide
A02BX11
Adult Dosing
- 100 mg orally three times daily, typically administered after meals
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Gastritis
- Gastric ulcer
- Improvement of gastric mucosal lesions (erosion, bleeding, redness, and edema) in acute gastritis and acute exacerbation of chronic gastritis
Mechanism of Action
- Gastric mucosal protective agent that increases gastric mucosal blood flow
- Stimulates the synthesis and secretion of gastric mucus and prostaglandins
- Scavenges reactive oxygen species and inhibits inflammatory cytokine production in gastric mucosa
Contraindications
- Hypersensitivity to troxipide or any component of the formulation
- Severe hepatic impairment (use with caution or avoid)
- Pregnancy and lactation (unless clinically necessary due to lack of adequate safety data)
Adverse Reactions
- Constipation
- Diarrhea
- Nausea and vomiting
- Abdominal discomfort or pain
- Elevated liver enzymes (AST, ALT)
- Rash or pruritus
Drug Interactions
- No major clinically significant pharmacokinetic drug interactions have been formally documented
- May theoretically interact with other agents affecting gastric pH or motility, though clinical significance is low
Curated Content: Needs Vetting Before Put to Clinical Use