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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR ACID RELATED DISORDERS › DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) › Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
carbenoxolone, combinations excl. psycholeptics
A02BX51
Forms & Strengths
- Oral gel: 2%
- Dental paste: 2%
Adult Dosing
- Aphthous ulceration: Apply small amount of gel or paste to the affected area 2 to 4 times daily after meals.
Pediatric Dosing
- Children >12 years: Same as adult dosing.
- Children <12 years: Safety and efficacy not well established; use with caution.
Indications
- Treatment of aphthous ulcers and minor inflammatory conditions of the oral mucosa.
Mechanism of Action
- Exerts anti-inflammatory and mineralocorticoid-like effects.
- Promotes healing of oral mucosal lesions by increasing mucus production and reducing inflammation.
Contraindications
- Hypersensitivity to carbenoxolone or any component of the formulation
- Severe cardiovascular disease (e.g., congestive heart failure, severe hypertension)
- Severe renal impairment
- Hypokalemia
Adverse Reactions
- Sodium and water retention
- Edema
- Hypokalemia
- Hypertension
- Local irritation or hypersensitivity reactions at the application site
Drug Interactions
- Cardiac glycosides (digoxin): Increased toxicity risk due to carbenoxolone-induced hypokalemia.
- Diuretics (thiazides, loop diuretics): Increased risk of severe hypokalemia and electrolyte imbalances.
- Antihypertensive agents: Decreased efficacy due to sodium and water retention.
Curated Content: Needs Vetting Before Put to Clinical Use