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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › Synthetic anticholinergics, esters with tertiary amino group
camylofin
A03AA03
Forms & Strengths
- Tablet: 50 mg
- Solution for injection: 50 mg/2 mL
Adult Dosing
- Oral: 50 mg to 100 mg up to 3 times daily
- Intramuscular or Intravenous: 50 mg as a single dose, may be repeated if necessary
Pediatric Dosing
- Safety and efficacy in pediatric patients not well established; use generally avoided or restricted based on age and weight under strict medical supervision
Indications
- Relief of visceral smooth muscle spasms
- Gastrointestinal colic
- Biliary and renal colic
- Dysmenorrhea
Mechanism of Action
- Direct relaxation of visceral smooth muscle via musculotropic action
- Exhibits mild anticholinergic (antimuscarinic) properties contributing to spasmolysis
Contraindications
- Hypersensitivity to camylofin
- Glaucoma (narrow-angle)
- Prostatic hyperplasia with urinary retention
- Tachyarrhythmias
- Mechanical gastrointestinal obstruction
- Megacolon
Adverse Reactions
- Dry mouth
- Blurred vision
- Tachycardia
- Dizziness
- Urinary retention
- Constipation
- Allergic skin reactions
Drug Interactions
- Enhanced anticholinergic effects when co-administered with tricyclic antidepressants, antihistamines, or antiparkinsonian agents
- Potential antagonism of gastrointestinal prokinetic agents (e.g., metoclopramide, domperidone)
Curated Content: Needs Vetting Before Put to Clinical Use