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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › Synthetic anticholinergics, esters with tertiary amino group
rociverine
A03AA06
Forms & Strengths
- Oral capsules 10 mg
- Oral drops 2%
Adult Dosing
- 10 mg to 20 mg orally 2 to 3 times daily
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
Indications
- Symptomatic relief of painful spasms of the gastrointestinal tract
- Biliary tract dyskinesia and spasms
- Urinary tract spasms
Mechanism of Action
- Antispasmodic agent acting directly on smooth muscle of the gastrointestinal, biliary, and urinary tracts
- Exhibits mild anticholinergic-like properties to reduce smooth muscle hypermotility and pain
Contraindications
- Known hypersensitivity to rociverine
- Glaucoma
- Prostatic hypertrophy with urinary retention
- Mechanical gastrointestinal stenosis or obstruction
- Paralytic ileus
Adverse Reactions
- Dry mouth
- Blurred vision
- Dizziness
- Nausea
- Mild urinary hesitancy
Drug Interactions
- Enhancement of anticholinergic side effects when co-administered with tricyclic antidepressants
- Potential potentiation of sedative effects with central nervous system depressants
Curated Content: Needs Vetting Before Put to Clinical Use