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tiemonium iodide

A03AB17

Forms & Strengths

Tablet 50 mg
Syrup 10 mg/5 mL
Injection 5 mg/2 mL

Adult Dosing

Oral: 50 to 150 mg (1 to 3 tablets) daily in divided doses
Intramuscular or intravenous: 5 to 10 mg as needed, repeated up to 3 times daily in acute spasm

Pediatric Dosing

Safety and efficacy in pediatric patients not well established; use requires careful weight-based dose adjustment by a clinician

Indications

Symptomatic relief of acute painful spasms of the gastrointestinal tract, biliary tract, and urogenital tract
Visceral colic
Dysmenorrhea

Mechanism of Action

Competitive antagonism at peripheral muscarinic acetylcholine receptors (anticholinergic)
Direct antispasmodic effect on smooth muscle fibers of the visceral organs

Contraindications

Known hypersensitivity to tiemonium iodide or other anticholinergics
Glaucoma (angle-closure)
Risk of urinary retention related to urethral-prostatic disorders
Paralytic ileus or toxic megacolon

Adverse Reactions

Dry mouth
Blurred vision
Constipation
Urinary retention
Palpitations or tachycardia
Drowsiness or dizziness

Drug Interactions

Concomitant use with other anticholinergic agents (e.g., tricyclic antidepressants, antihistamines, amantadine) increases the risk of anticholinergic side effects
May decrease gastrointestinal absorption of other concurrently administered oral medications due to slowed motility

Curated Content: Needs Vetting Before Put to Clinical Use