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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › Synthetic antispasmodics, amides with tertiary amines
dimethylaminopropionylphenothiazine
A03AC02
Forms & Strengths
- Oral tablets 10mg
- Oral tablets 25mg
- Injectable solution 25mg/2ml
Adult Dosing
- 10-20mg orally three to four times a day
- 25mg orally at bedtime for insomnia
- 25mg intramuscularly or intravenously for severe nausea and vomiting
Pediatric Dosing
- 5-10mg orally three times a day for children over 12 years
- 2.5-5mg orally three times a day for children under 12 years
Indications
- Gastrointestinal disorders
- Nausea and vomiting
- Insomnia
- Anxiety
- Psychotic disorders
Mechanism of Action
- Antihistamine properties
- Anticholinergic effects
- Central nervous system depressant
- Dopamine antagonist
Contraindications
- Hypersensitivity to phenothiazine derivatives
- Severe heart disease
- Narrow-angle glaucoma
- Prostate hypertrophy
- Pregnancy and lactation
Adverse Reactions
- Drowsiness
- Dry mouth
- Constipation
- Urinary retention
- Orthostatic hypotension
- Extrapyramidal symptoms
Drug Interactions
- Central nervous system depressants
- Antihypertensives
- Anticholinergics
- Tricyclic antidepressants
- Monoamine oxidase inhibitors
Curated Content: Needs Vetting Before Put to Clinical Use