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chlorbenzoxamine

A03AX03

Forms & Strengths

Oral tablets: 10 mg
Combination formulations exist with antispasmodics or sedatives depending on regional availability

Adult Dosing

10 to 20 mg orally three times daily before meals
Maximum daily dose generally not to exceed 60 mg

Pediatric Dosing

Safety and efficacy in pediatric patients not established
Use in children is generally not recommended

Indications

Symptomatic relief of gastrointestinal hypermotility
Visceral spasms associated with irritable bowel syndrome and gastritis

Mechanism of Action

Anticholinergic and antispasmodic agent
Exerts direct relaxant effects on gastrointestinal smooth muscle
Competitively blocks muscarinic acetylcholine receptors to reduce secretions and motility

Contraindications

Known hypersensitivity to chlorbenzoxamine
Angle-closure glaucoma
Gastrointestinal tract obstruction, paralytic ileus, or toxic megacolon
Severe obstructive uropathy or prostatic hyperplasia with urinary retention
Myasthenia gravis

Adverse Reactions

Dry mouth, blurred vision, and mydriasis
Constipation and urinary retention
Tachycardia and palpitations
Drowsiness, dizziness, and headache
Reduced sweating leading to potential heat intolerance

Drug Interactions

Additive anticholinergic effects with tricyclic antidepressants, antihistamines, and antiparkinsonian drugs
May alter gastrointestinal absorption of other oral medications due to decreased motility
Enhances sedative effects when co-administered with central nervous system depressants or alcohol

Curated Content: Needs Vetting Before Put to Clinical Use