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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › Other drugs for functional gastrointestinal disorders
caroverine
A03AX11
Forms & Strengths
- Oral capsules: 20 mg, 40 mg
- Intravenous solution: 20 mg/2 mL
Adult Dosing
- Spasmolysis (gastrointestinal): 40 mg to 80 mg orally up to 3 times daily
- Acute tinnitus: 40 mg to 80 mg intravenously or orally, tailored to clinical response
Pediatric Dosing
- Safety and efficacy in pediatric patients not established; use generally not recommended
Indications
- Spasms of the gastrointestinal tract
- Acute inner ear tinnitus
Mechanism of Action
- Acts as a non-competitive antagonist at AMPA and NMDA glutamate receptors in the cochlea for tinnitus
- Exerts a direct papaverine-like myotropic antispasmodic effect on smooth muscle tissue in the GI tract
Contraindications
- Hypersensitivity to caroverine
- Severe hepatic or renal impairment
- Paralytic ileus
- Severe cardiovascular instability
Adverse Reactions
- Dizziness
- Dry mouth
- Transient visual disturbances
- Mild gastrointestinal upset
- Hypotension with rapid intravenous administration
Drug Interactions
- Enhancement of anticholinergic effects when co-administered with other anticholinergic agents
- Potential additive CNS depression with sedatives, hypnotics, or alcohol
Curated Content: Needs Vetting Before Put to Clinical Use