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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › Other drugs for functional gastrointestinal disorders
trimethyldiphenylpropylamine
A03AX30
Forms & Strengths
- Oral tablets: 40 mg
- Suppositories: 20 mg
- Oral drops: 20 mg/mL
Adult Dosing
- 40 mg orally 3 times daily before meals
- Rectal: 20-40 mg up to 3 times daily as needed for acute spasm
Pediatric Dosing
- Not recommended for children under 6 years of age
- Children 6-12 years: 20 mg orally 2-3 times daily
Indications
- Symptomatic treatment of gastrointestinal motility disorders
- Spastic conditions of the gastrointestinal tract
- Irritable bowel syndrome (IBS) associated with spasm
Mechanism of Action
- Direct antispasmodic action on smooth muscle of the gastrointestinal tract
- Exerts a papaverine-like myotropic effect independent of autonomic innervation
Contraindications
- Known hypersensitivity to trimethyldiphenylpropylamine or excipients
- Paralytic ileus
- Mechanical gastrointestinal obstruction
- Severe toxic megacolon
Adverse Reactions
- Dry mouth
- Nausea
- Mild dizziness
- Drowsiness
- Allergic skin reactions
Drug Interactions
- Enhanced anticholinergic side effects when co-administered with tricyclic antidepressants
- May alter gastrointestinal absorption of concurrently administered oral medications due to motility changes
Curated Content: Needs Vetting Before Put to Clinical Use