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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS › Synthetic anticholinergic agents in combination with psycholeptics
isopropamide and psycholeptics
A03CA01
Forms & Strengths
- isopropamide 5mg + psycholeptics (various strengths)
- Tablets
- Oral solution
Adult Dosing
- 1 to 2 tablets orally 3 to 4 times a day
- Maximum dose: 8 tablets per day
- Dose adjustment for renal impairment: reduce dose by 50%
- Dose adjustment for hepatic impairment: reduce dose by 25%
Pediatric Dosing
- Not recommended for children under 12 years old
- For children 12 to 18 years old: half the adult dose
Indications
- Treatment of gastrointestinal disorders (e.g., irritable bowel syndrome, peptic ulcer disease)
- Adjunctive treatment of anxiety and stress
Mechanism of Action
- Isopropamide: anticholinergic and antispasmodic properties
- Psycholeptics: anxiolytic, sedative, and tranquilizing effects
Contraindications
- Hypersensitivity to isopropamide or psycholeptics
- Narrow-angle glaucoma
- Myasthenia gravis
- Intestinal obstruction
Adverse Reactions
- Dry mouth
- Dizziness
- Drowsiness
- Urinary retention
- Constipation
Drug Interactions
- Increased risk of anticholinergic effects with other anticholinergic agents
- Enhanced sedative effects with CNS depressants (e.g., benzodiazepines, opioids)
- Increased risk of extrapyramidal symptoms with neuroleptics
Curated Content: Needs Vetting Before Put to Clinical Use