← Search & browse all drugs
ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS › Synthetic anticholinergic agents in combination with psycholeptics
diphemanil and psycholeptics
A03CA08
Forms & Strengths
- Tablets: 20mg, 30mg, 50mg
- Injectable solution: 10mg/mL, 20mg/mL
- Suppositories: 20mg, 50mg
Adult Dosing
- Oral: 20-50mg three to four times daily
- Parenteral: 10-20mg every 4-6 hours
- Maximum daily dose: 200mg
Pediatric Dosing
- Not recommended for children under 12 years old
- 12 years and older: 10-20mg every 4-6 hours
Indications
- Treatment of gastrointestinal disorders
- Gastroesophageal reflux disease
- Diarrhea
- Irritable bowel syndrome
Mechanism of Action
- Anticholinergic activity
- Blocks acetylcholine receptors
- Reduces smooth muscle contractions
- Inhibits gastric secretions
Contraindications
- Hypersensitivity to diphemanil or similar compounds
- Narrow-angle glaucoma
- Obstructive uropathy
- Severe ulcerative colitis
Adverse Reactions
- Dry mouth
- Dizziness
- Blurred vision
- Constipation
- Urinary retention
Drug Interactions
- Antihistamines: enhanced sedation
- Opioids: increased risk of constipation
- Muscarinic blockers: additive anticholinergic effects
- Antacids: reduced diphemanil absorption
Curated Content: Needs Vetting Before Put to Clinical Use