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propantheline and psycholeptics

A03CA34

Forms & Strengths

Propantheline bromide 15mg tablets
Propantheline bromide 30mg tablets
Propantheline bromide 15mg/5mL oral solution

Adult Dosing

15-30mg orally three to four times daily
Maximum daily dose: 120mg
Dose adjustment may be necessary for renal or hepatic impairment

Pediatric Dosing

Safety and efficacy not established in pediatric patients
Use with caution in pediatric patients, dose not established

Indications

Treatment of peptic ulcer disease
Gastroesophageal reflux disease (GERD)
Irritable bowel syndrome (IBS)
Gastroparesis

Mechanism of Action

Competitive inhibition of acetylcholine at muscarinic receptors
Reduces gastrointestinal motility and secretions
Anticholinergic effects: decreased gastric acid secretion, decreased GI motility

Contraindications

Myasthenia gravis
Narrow-angle glaucoma
Obstructive uropathy
Obstructive diseases of the gastrointestinal tract
Ulcerative colitis

Adverse Reactions

Dry mouth, blurred vision, urinary retention
Constipation, decreased sweating, orthostatic hypotension
Tachycardia, palpitations, confusion, disorientation
Nausea, vomiting, dizziness, headache

Drug Interactions

Antihistamines: increased risk of anticholinergic side effects
Opioid analgesics: increased risk of constipation and urinary retention
Antidepressants (tricyclic): increased risk of anticholinergic side effects
Nitrates: decreased absorption of nitrates

Curated Content: Needs Vetting Before Put to Clinical Use