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acotiamide

A03FA10

Forms & Strengths

Oral tablets: 100 mg

Adult Dosing

100 mg orally three times daily, taken before meals

Pediatric Dosing

Safety and efficacy in pediatric patients have not been established

Indications

Treatment of upper gastrointestinal symptoms associated with functional dyspepsia (postprandial distress syndrome)

Mechanism of Action

Acetylcholinesterase inhibitor that enhances gastrointestinal motility
Increases release of acetylcholine in the enteric nervous system by blocking presynaptic muscarinic autoreceptors
Facilitates gastric emptying and improves gastric accommodation

Contraindications

Hypersensitivity to acotiamide or any excipients
Patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation

Adverse Reactions

Diarrhea
Constipation
Elevated serum prolactin
Liver function test abnormalities (ALT, AST elevations)
Leukopenia

Drug Interactions

Anticholinergic agents may antagonize the gastrointestinal prokinetic effects of acotiamide
No clinically significant cytochrome P450 drug-interactions identified based on in vitro metabolism profiles

Curated Content: Needs Vetting Before Put to Clinical Use