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ALIMENTARY TRACT AND METABOLISM › BILE AND LIVER THERAPY › BILE THERAPY › Bile acids and derivatives
obeticholic acid
A05AA04
Forms & Strengths
- 6mg and 10mg oral tablets
- 5mg and 10mg oral capsules for certain markets
Adult Dosing
- 5mg to 10mg orally once daily for primary biliary cholangitis
- 5mg orally once daily, titrate as needed and tolerated
Pediatric Dosing
- not established for patients under 18 years for primary biliary cholangitis
Indications
- treatment of primary biliary cholangitis in combination with ursodeoxycholic acid in adults with an inadequate response to ursodeoxycholic acid or as monotherapy in adults unable to tolerate ursodeoxycholic acid
Mechanism of Action
- farnesoid X receptor agonist, which reduces the production of bile acids and increases their excretion into the feces
Contraindications
- complete biliary obstruction
Adverse Reactions
- pruritus, fatigue, abdominal pain, diarrhea, constipation, rash, oropharyngeal pain, peripheral edema
Drug Interactions
- bile acid binding resins, which may decrease obeticholic acid absorption
Curated Content: Needs Vetting Before Put to Clinical Use