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ALIMENTARY TRACT AND METABOLISM › BILE AND LIVER THERAPY › BILE THERAPY › Other drugs for bile therapy
hymecromone
A05AX02
Adult Dosing
- 200 mg to 400 mg orally 3 times daily before meals
- Duration of treatment typically depends on clinical response and specific biliary indication
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established; use is generally not recommended
Indications
- Treatment of spasm and dyskinesia of the biliary tract
- Symptomatic relief of disorders of the biliary system and sphincter of Oddi dysfunction
- Adjunct therapy in cholelithiasis and post-cholecystectomy syndrome
Mechanism of Action
- Acts as a choleretic and antispasmodic agent
- Selectively relaxes the sphincter of Oddi and smooth muscle of the bile ducts
- Increases the volume and flow of bile, reducing biliary stasis
Contraindications
- Hypersensitivity to hymecromone or any excipients
- Complete biliary tract obstruction
- Severe hepatic impairment
- Severe renal impairment
- Active peptic ulcer disease or inflammatory bowel disease
Adverse Reactions
- Diarrhea
- Abdominal pain and cramping
- Nausea and vomiting
- Allergic skin reactions (rash, pruritus)
- Headache
Drug Interactions
- Morphine and other opioid analgesics may antagonize the spasmolytic biliary effects
- Anticholinergic drugs may enhance antispasmodic effects
- May alter the absorption of concurrently administered oral medications due to increased bile flow and gastrointestinal motility
Curated Content: Needs Vetting Before Put to Clinical Use