← Search & browse all drugs
ALIMENTARY TRACT AND METABOLISM › BILE AND LIVER THERAPY › BILE THERAPY › Other drugs for bile therapy
odevixibat
A05AX05
Forms & Strengths
- Capsules: 10 mg, 20 mg, 40 mg, 50 mg, 100 mg
- Oral pellets: 10 mg, 20 mg, 40 mg, 50 mg, 100 mg
- Oral suspension: 10 mg/mL
Adult Dosing
- Initial dose: 10 mg once daily with food
- Titrate to 20-50 mg once daily as needed and tolerated
- Maximum dose: 50 mg once daily
Pediatric Dosing
- 1-3 months: 0.5 mg/kg once daily with food
- 4-6 months: 1 mg/kg once daily with food
- 7 months-3 years: 5-10 mg once daily with food
- 4-11 years: 10-20 mg once daily with food
- 12-17 years: 10-50 mg once daily with food
Indications
- Alagille syndrome with cholestasis
- Progressive familial intrahepatic cholestasis (PFIC) type 2
Mechanism of Action
- Inhibits the ileal bile acid transporter (IBAT) to reduce bile acid reabsorption
- Increases bile acid excretion in the feces
- Decreases systemic exposure to toxic bile acids
Contraindications
- Hypersensitivity to odevixibat or excipients
- Complete biliary obstruction
Adverse Reactions
- Diarrhea
- Fever
- Fatigue
- Vomiting
- Abdominal pain
- Elevated liver enzymes
Drug Interactions
- CYP3A4 inhibitors: potential for increased odevixibat concentrations
- CYP3A4 inducers: potential for decreased odevixibat concentrations
- Bile acid sequestrants: potential for decreased odevixibat efficacy
Curated Content: Needs Vetting Before Put to Clinical Use