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ALIMENTARY TRACT AND METABOLISM › BILE AND LIVER THERAPY › LIVER THERAPY, LIPOTROPICS › Liver therapy
epomediol
A05BA05
Forms & Strengths
- Oral capsules: 250 mg
- Intravenous injection: 500 mg/5 mL
Adult Dosing
- Oral: 250 mg to 500 mg three times daily before meals
- Intravenous: 500 mg daily administered slowly
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Treatment of intrahepatic cholestasis
- Management of acute and chronic liver disorders associated with altered bile secretion
Mechanism of Action
- Acts as a choleretic agent to stimulate bile flow and secretion
- Enhances hepatocellular function and membrane fluidity to reduce intrahepatic cholestasis
Contraindications
- Hypersensitivity to epomediol or any excipients
- Complete mechanical biliary obstruction
- Severe hepatocellular failure
Adverse Reactions
- Mild gastrointestinal disturbances (nausea, abdominal discomfort)
- Transient elevation of serum transaminases
- Allergic skin reactions
Drug Interactions
- May alter the absorption of concomitantly administered oral medications due to increased gastrointestinal motility and bile flow
- No major cytochrome P450-mediated drug interactions formally documented
Curated Content: Needs Vetting Before Put to Clinical Use