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ALIMENTARY TRACT AND METABOLISM › BILE AND LIVER THERAPY › LIVER THERAPY, LIPOTROPICS › Liver therapy
glycyrrhizic acid
A05BA08
Forms & Strengths
- Intravenous infusion: 40 mg/20 mL
- Oral tablets/capsules: 25 mg, 50 mg
- Topical gel/cream: 2%
- Ophthalmic solution: 0.1%
Adult Dosing
- Chronic hepatitis: 40 to 80 mg IV once daily
- Oral supplementation: 50 to 150 mg daily in divided doses
- Topical: Apply thin layer to affected area 2 to 4 times daily
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
- Use in children generally discouraged due to mineralocorticoid side effects
Indications
- Adjunctive treatment for chronic viral hepatitis
- Inflammatory skin conditions (topical)
- Canker sores and oral mucositis
Mechanism of Action
- Inhibits 11-beta-hydroxysteroid dehydrogenase, reducing cortisol inactivation
- Exerts anti-inflammatory and immunomodulatory effects
- Demonstrates hepatoprotective activity by inhibiting hepatocellular apoptosis
Contraindications
- Hypersensitivity to glycyrrhizic acid or licorice derivatives
- Severe hypertension
- Hypokalemia
- Cirrhosis with hepatic encephalopathy
- Pregnancy and lactation
Adverse Reactions
- Pseudohyperaldosteronism
- Hypertension
- Hypokalemia
- Edema and weight gain
- Headache and lethargy
Drug Interactions
- Thiazide and loop diuretics (synergistic hypokalemia)
- Cardiac glycosides/digoxin (increased toxicity due to hypokalemia)
- Antihypertensive agents (decreased efficacy)
- Corticosteroids (potentiated mineralocorticoid effects)
Curated Content: Needs Vetting Before Put to Clinical Use