← Search & browse all drugs
ALIMENTARY TRACT AND METABOLISM › DRUGS FOR CONSTIPATION › DRUGS FOR CONSTIPATION › Softeners, emollients
docusate sodium
A06AA02
Forms & Strengths
- 100mg capsules
- 240mg tablets
- 50mg/5mL oral liquid
- 100mg/5mL oral liquid
- 10% enema solution
Adult Dosing
- 50-300mg orally per day in 1-3 divided doses
- For constipation: 100-300mg per day
- Stool softener: 50-100mg per day
Pediatric Dosing
- Infants under 3 years: not recommended
- Children 3-6 years: 20-40mg per day
- Children 6-12 years: 40-60mg per day
Indications
- Relief of constipation
- Stool softener for hard, dry stools
- Prevention of constipation in patients with conditions that may lead to constipation
Mechanism of Action
- Increases water and electrolyte absorption in the intestines
- Softens stool by increasing the amount of water the stool absorbs in the gut
- Reduces surface tension of stool to allow for easier passage
Contraindications
- Hypersensitivity to docusate
- Intestinal obstruction
- Untreated abdominal pain
- Severe inflammatory conditions of the intestines
Adverse Reactions
- Gastrointestinal irritation
- Throat irritation
- Rash
- Pruritus
- Diarrhea
Drug Interactions
- Mineral oil: may increase the risk of lipoid pneumonia
- Vitamin and mineral supplements: may decrease absorption of fat-soluble vitamins
Curated Content: Needs Vetting Before Put to Clinical Use