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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR CONSTIPATION › DRUGS FOR CONSTIPATION › Osmotically acting laxatives
magnesium oxide
A06AD02
Forms & Strengths
- Tablet: 200-800 mg
- Capsule: 140-500 mg
- Powder: variable
- Liquid: 400-1200 mg/5mL
Adult Dosing
- Constipation: 400-1200 mg PO once daily
- Mild laxative: 300-600 mg PO once daily
- Antacid: 400-800 mg PO as needed
Pediatric Dosing
- Children 6-12 years: 100-200 mg PO once daily
- Children under 6 years: consult a healthcare professional
Indications
- Constipation
- Mild bowel irregularity
- Heartburn and acid indigestion relief
- Migraine prophylaxis
Mechanism of Action
- Increases water in the intestines to induce defecation
- Neutralizes gastric acid to relieve heartburn
Contraindications
- Gastrointestinal obstruction
- Undiagnosed abdominal pain
- Kidney failure
Adverse Reactions
- Gastrointestinal cramps
- Diarrhea
- Flatus
Drug Interactions
- Tetracyclines: decreased absorption
- Warfarin: decreased efficacy
- Quinolone antibiotics: decreased absorption
Curated Content: Needs Vetting Before Put to Clinical Use