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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR CONSTIPATION › DRUGS FOR CONSTIPATION › Osmotically acting laxatives
lactitol
A06AD12
Forms & Strengths
- Powder for oral solution: 10g, 20g
- Tablets: 500mg, 700mg
Adult Dosing
- 10-20g per day for constipation
- 1.5-2.5g tid for hepatic encephalopathy
Pediatric Dosing
- 0.5-1.5g per day for children over 6 years with constipation
- Age and dose must be determined by a healthcare provider
Indications
- Treatment of constipation
- Management of hepatic encephalopathy
Mechanism of Action
- Osmotic laxative, increasing stool water content
- Inhibiting ammonia production in colon by intestinal bacteria
Contraindications
- Hypersensitivity to lactitol
- Intestinal obstruction, perforation or risk of these conditions
Adverse Reactions
- Flatulence
- Diarrhea
- Abdominal pain or discomfort
- Bloating and gas
Drug Interactions
- May decrease absorption of concomitantly administered medications
- Reduced efficacy with concomitant use of antacids, histamine-2 blockers
Curated Content: Needs Vetting Before Put to Clinical Use