← Search & browse all drugs

sodium sulfate

A06AD13

Forms & Strengths

Oral solution: sodium sulfate 17.5 g, potassium chloride 3.13 g, magnesium sulfate 1.6 g per 177 mL

Adult Dosing

Colonoscopy preparation: Two-dose split regimen. Dose 1: One bottle evening before procedure, followed by 16 oz water over 1 hour. Dose 2: Second bottle morning of procedure (10-12 hours later), followed by 16 oz water over 1 hour, completed at least 2 hours prior to colonoscopy.

Pediatric Dosing

Safety and efficacy not established in pediatric patients < 16 years of age

Indications

Cleansing of the colon as a preparation for colonoscopy in adults

Mechanism of Action

Osmotic action of sulfate salts retains water in the intestinal lumen, causing water retention, distention, and diarrhea, leading to rapid evacuation of the colon.

Contraindications

Gastrointestinal obstruction or ileus
Bowel perforation
Toxic colitis or toxic megacolon
Gastric retention
Hypersensitivity to any component of the formulation

Adverse Reactions

Overall discomfort
Abdominal distention
Hyperuricemia
Nausea
Vomiting
Sleep disorder
Electrolyte disturbances (hypokalemia, hyponatremia)

Drug Interactions

Drugs that increase risk of fluid and electrolyte disturbances (diuretics, ACE inhibitors, ARBs)
Oral medications taken within 1 hour of starting each dose may be flushed from the GI tract and not absorbed

Curated Content: Needs Vetting Before Put to Clinical Use