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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR CONSTIPATION › DRUGS FOR CONSTIPATION › Osmotically acting laxatives
pentaerithrityl
A06AD14
Adult Dosing
- Dosing depends on specific formulation and clinical indication for bowel evacuation or constipation management; refer to local product labeling.
Pediatric Dosing
- Safety and efficacy in pediatric populations not well established; use with caution and per specialist recommendation.
Indications
- Constipation management
- Bowel cleansing prior to diagnostic or surgical procedures
Mechanism of Action
- Acts as an osmotic laxative, retaining water in the intestinal lumen to soften stool and stimulate peristalsis.
Contraindications
- Gastrointestinal obstruction
- Bowel perforation
- Severe inflammatory bowel disease
- Hypersensitivity to pentaerythritol or related osmotic agents
Adverse Reactions
- Abdominal pain
- Bloating
- Nausea
- Diarrhea
- Electrolyte imbalance with excessive use
Drug Interactions
- May decrease absorption of concomitantly administered oral medications due to accelerated gastrointestinal transit.
Curated Content: Needs Vetting Before Put to Clinical Use