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magnesium citrate

A06AD19

Forms & Strengths

Oral solution: magnesium citrate 1.745 g/30 mL (approximately 1.745 g magnesium citrate per fluid ounce)

Adult Dosing

Constipation: 195 to 300 mL (one full bottle) as a single dose or divided into two doses
Bowel cleansing prior to procedures: 296 mL (one bottle) afternoon/evening prior to procedure, followed by 8 oz water; may repeat dose if necessary

Pediatric Dosing

Children 2 to 6 years: 0.5 mL/kg up to a maximum of 100 mL
Children 6 to 12 years: 100 to 150 mL as a single dose
Children 12 years and older: 195 to 300 mL as a single dose

Indications

Short-term treatment of occasional constipation
Cleansing of the bowel prior to diagnostic or surgical procedures

Mechanism of Action

Acts as a hyperosmotic laxative by drawing water into the intestinal lumen, increasing intraluminal pressure and stimulating peristalsis
Stimulates the release of cholecystokinin, further enhancing fluid accumulation and gastrointestinal motility

Contraindications

Hypersensitivity to magnesium or any component of the formulation
Severe renal impairment (risk of hypermagnesemia)
Gastrointestinal obstruction, ileus, or bowel perforation
Acute surgical abdomen, appendicitis, or undiagnosed abdominal pain
Colostomy or ileostomy without medical supervision

Adverse Reactions

Abdominal cramping, pain, and distention
Nausea and vomiting
Diarrhea and excessive fluid loss leading to dehydration
Electrolyte disturbances (hypokalemia, hypocalcemia, hypermagnesemia with renal impairment)

Drug Interactions

May decrease the absorption of concurrently administered oral medications due to accelerated gastrointestinal transit (e.g., fluoroquinolones, tetracyclines, iron, digoxin)
Increases risk of hypermagnesemia when used with other magnesium-containing medications (antacids, laxatives)
Additive electrolyte imbalances with loop or thiazide diuretics

Curated Content: Needs Vetting Before Put to Clinical Use