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sodium phosphate

A06AG01

Forms & Strengths

Enema: Monobasic sodium phosphate 19 g and dibasic sodium phosphate 7 g per 118 mL delivered volume
Oral solution: Monobasic sodium phosphate 48 g and dibasic sodium phosphate 18 g per 45 mL

Adult Dosing

Constipation/Bowel cleansing: One delivered enema (118 mL) rectally as a single dose
Colonoscopy preparation (Oral): 45 mL aqueous solution diluted in 4 ounces of clear liquids, followed by 8 ounces of clear liquids, repeated once (total 90 mL) as a split-dose regimen

Pediatric Dosing

Children 2 to 11 years: Rectal enema 59 mL (half-bottle) as a single dose, use with caution
Children under 2 years: Contraindicated for rectal enema use
Children under 18 years (Oral solution): Safety and efficacy not established, not recommended for bowel preparation

Indications

Treatment of occasional constipation
Bowel cleansing prior to colonoscopy, sigmoidoscopy, or radiological procedures

Mechanism of Action

Acts as an osmotic laxative in the intestinal tract
Draws water into the lumen of the colon via osmotic gradient
Increases intraluminal pressure and stimulates peristalsis

Contraindications

Congestive heart failure
Clinically significant renal impairment
Ascites
Suspected bowel obstruction, ileus, or perforation
Acute surgical abdomen or inflammatory bowel disease flares
Known hypersensitivity to sodium phosphate products

Adverse Reactions

Hyperphosphatemia
Hypocalcemia
Hypokalemia
Dehydration and electrolyte imbalances
Acute phosphate nephropathy (renal failure)
Abdominal pain, cramping, bloating, nausea, and vomiting
Rectal irritation or ulceration (with enema use)

Drug Interactions

Drugs that may affect electrolyte levels (diuretics, ACE inhibitors, ARBs, NSAIDs) increasing risk of nephrocalcinosis
Oral medications with absorption affected by rapid GI transit (may be flushed from the GI tract)
Calcium channel blockers and other agents that impair renal function

Curated Content: Needs Vetting Before Put to Clinical Use