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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR CONSTIPATION › DRUGS FOR CONSTIPATION › Other drugs for constipation
glycerol
A06AX01
Forms & Strengths
- oral liquid 75%
- rectal suppository 2-4g
- injectable 10% solution
- oral capsules 1-2g
Adult Dosing
- oral: 1-2 tablespoons tid-qid
- rectal: 1 suppository daily-bid
- injectable: 50-100mL IV slowly
Pediatric Dosing
- oral: 1-2 mL/kg tid-qid
- rectal: 1/4 to 1/2 adult dose
- injectable: not recommended
Indications
- constipation
- cathartic prior to radiologic examination
- reduction of intraocular pressure
Mechanism of Action
- osmotic effect in gut
- draws water into intestinal lumen
- stool softening and bowel evacuation
Contraindications
- known allergy to glycerol
- intestinal obstruction or perforation
- inflammatory bowel disease
Adverse Reactions
- gastrointestinal cramps
- diarrhea
- abdominal distension
- headache
- nausea
Drug Interactions
- reduced absorption with mineral oil
- enhanced effect with bisacodyl or other laxatives
- potential interaction with warfarin
Curated Content: Needs Vetting Before Put to Clinical Use