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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR CONSTIPATION › DRUGS FOR CONSTIPATION › Other drugs for constipation
tegaserod
A06AX06
Forms & Strengths
- Tablets: 2 mg, 6 mg
- Oral tablets are available in 2 mg and 6 mg strengths
Adult Dosing
- For irritable bowel syndrome (IBS) with constipation: 6 mg orally twice daily
- For chronic idiopathic constipation: 6 mg orally twice daily
Pediatric Dosing
- Not recommended for use in pediatric patients under 18 years old
Indications
- Treatment of irritable bowel syndrome with constipation (IBS-C) in women
- Treatment of chronic idiopathic constipation in adults
Mechanism of Action
- Selective serotonin 5-HT4 receptor agonist
- Increases peristalsis and promotes gastrointestinal motility
Contraindications
- History of myocardial infarction
- History of stroke
- History of transient ischemic attack
- Diarrhea
Adverse Reactions
- Diarrhea
- Headache
- Abdominal pain
- Nausea
- Flatulence
Drug Interactions
- Fluconazole: increases tegaserod exposure
- Grapefruit juice: may increase tegaserod exposure
Curated Content: Needs Vetting Before Put to Clinical Use