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ALIMENTARY TRACT AND METABOLISM › DRUGS FOR CONSTIPATION › DRUGS FOR CONSTIPATION › Other drugs for constipation
elobixibat
A06AX09
Adult Dosing
- Chronic constipation: 10 mg orally once daily, taken before breakfast; may be adjusted based on response up to 15 mg once daily.
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established.
Indications
- Treatment of chronic constipation (excluding chronic constipation caused by organic diseases)
Mechanism of Action
- Inhibitor of the ileal bile acid transporter (IBAT); blocks bile acid reabsorption in the terminal ileum, increasing bile acid concentrations in the colon which stimulates colonic motility and fluid secretion.
Contraindications
- Known hypersensitivity to elobixibat or any component of the formulation
- Patients with known or suspected intestinal obstruction
- Severe inflammatory bowel disease
Adverse Reactions
- Abdominal pain
- Diarrhea
- Abdominal discomfort
- Nausea
Drug Interactions
- Bile acid sequestrants (e.g., cholestyramine, colesevelam) may bind to elobixibat or reduce its efficacy; administer at least several hours apart.
- OATP inhibitors may increase systemic exposure of elobixibat.
Curated Content: Needs Vetting Before Put to Clinical Use