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natamycin

A07AA03

Forms & Strengths

Suspension for oral administration: 100 mg/10 mL and 500 mg/10 mL
Vaginal tablet: 100 mg
Ophthalmic suspension: 5% (50 mg/mL)

Adult Dosing

Oral: 100 mg four times daily for 14 days for intestinal infections
Vaginal: 100 mg intravaginally once daily for 14 days
Ophthalmic: 1 drop of 5% suspension four times daily

Pediatric Dosing

Oral: 10-20 mg/kg four times daily for 14 days for intestinal infections
Vaginal (adolescents): same as adult dosing
Ophthalmic: same as adult dosing, adjusted according to age and response

Indications

Treatment of fungal infections of the intestinal tract
Treatment of vulvovaginal candidiasis
Treatment of fungal conjunctivitis and blepharitis

Mechanism of Action

Natamycin binds to ergosterol in fungal cell membranes, forming pores that allow leakage of vital cell nutrients and ions, leading to fungal cell death
Polyene antifungal with broad-spectrum fungicidal activity against various fungi

Contraindications

Hypersensitivity to natamycin or other polyene antifungals
Vaginal use in pregnant women, except in life-threatening situations

Adverse Reactions

Gastrointestinal: nausea, vomiting, diarrhea, abdominal pain
Vaginal: vulvar itching, burning, pelvic pain
Ophthalmic: stinging, burning, redness, blurred vision

Drug Interactions

Increased risk of nephrotoxicity when used concomitantly with other nephrotoxic agents
Potential for decreased efficacy when used with certain antacids or histamine-2 (H2) blockers

Curated Content: Needs Vetting Before Put to Clinical Use