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ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › INTESTINAL ANTIINFECTIVES › Antibiotics
colistin
A07AA10
Forms & Strengths
- Colistin sulfate powder for injection 50mg/vial
- Colistin sulfate powder for injection 100mg/vial
- Colistin base 150mg capsules
Adult Dosing
- 2.5 to 5mg/kg/day IV in 2-4 divided doses
- 150mg orally every 8-12 hours
Pediatric Dosing
- 5mg/kg/day, given in 2-4 divided doses
- 0-1 month: 2.5-5mg/kg IV q12h, 1-12 months: 2.5-5mg/kg IV q8h
- 1-12 years: 150-300mg/day PO, in 3-4 divided doses
- 12 years and older, 150mg every 12 hours
Indications
- Treatment of acute and chronic infections due to sensitive strains
- Pseudomonas aeruginosa infections
- Urinary tract infections
Mechanism of Action
- Binds to the bacterial cell membrane and disrupts its structure
- Interferes with cell membrane permeability
- Causes bacterial cell death
Contraindications
- Known hypersensitivity to colistin or any component of the formulation
- Myasthenia gravis
- Acute or chronic renal failure
Adverse Reactions
- Nephrotoxicity
- Neurotoxicity
- Respiratory distress
- Hypersensitivity reactions
- Nausea and vomiting
Drug Interactions
- Succinylcholine: colistin may increase muscle weakness
- Neuromuscular blockers: colistin may increase risk of respiratory failure
- Aminoglycosides: colistin may increase nephrotoxicity risk
Curated Content: Needs Vetting Before Put to Clinical Use