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ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › INTESTINAL ANTIINFECTIVES › Antibiotics
rifamycin
A07AA13
Forms & Strengths
- Capsules: 150mg, 300mg
- Tablets: 150mg, 300mg
- Oral suspension: 20mg/mL
Adult Dosing
- For travelers diarrhea: 1 capsule of 388mg, 1 dose
- For hepatic encephalopathy: 1-2 capsules of 550mg PO BID
- For Clostridium difficile infection: variable dosing
Pediatric Dosing
- For children over 12 years: same as adult dose for travelers diarrhea
- For children under 12 years: 10mg/kg/dose, 1 dose for travelers diarrhea
Indications
- Treatment of travelers diarrhea caused by E. coli
- Reduction in risk of overt hepatic encephalopathy recurrence
- Treatment of Clostridium difficile-associated diarrhea
Mechanism of Action
- Non-absorbable antibiotic
- Inhibits RNA synthesis in bacteria by binding to beta-subunit of RNA polymerase
- No systemic absorption, acts locally in gut
Contraindications
- Hypersensitivity to rifamycin or any component of the product
- Concurrent use with medications that are substrates for OATP1B1 and/or BCRP
Adverse Reactions
- Nausea, vomiting, diarrhea, abdominal pain, dyspepsia
- Headache, rash, pruritus, hypersensitivity reactions
Drug Interactions
- Potential decreased exposure to medications that are substrates for OATP1B1 and/or BCRP
- Avoid concomitant use with warfarin, methotrexate, and digoxin
Curated Content: Needs Vetting Before Put to Clinical Use