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ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › INTESTINAL ANTIINFECTIVES › Sulfonamides
succinylsulfathiazole
A07AB04
Adult Dosing
- Intestinal infections and preoperative bowel sterilization: 3 g to 5 g orally every 4 hours for 5 to 7 days, or as directed by clinical protocol.
Pediatric Dosing
- Safety and efficacy in pediatric patients not well established; use generally avoided or restricted based on specialized institutional protocols.
Indications
- Treatment of susceptible intestinal infections
- Preoperative suppression of intestinal bacterial flora
Mechanism of Action
- Sulfonamide derivative that acts locally within the gastrointestinal tract with minimal systemic absorption, inhibiting bacterial folic acid synthesis via competitive antagonism of para-aminobenzoic acid (PABA).
Contraindications
- Hypersensitivity to sulfonamides
- Intestinal obstruction
- Infants under 2 months of age due to risk of kernicterus
- Severe hepatic or renal impairment
Adverse Reactions
- Nausea
- Vomiting
- Diarrhea
- Abdominal discomfort
- Hypersensitivity reactions including skin rash and pruritus
- Rare hematologic abnormalities with prolonged use
Drug Interactions
- Oral anticoagulants (may enhance anticoagulant effect)
- Oral hypoglycemics (potential potentiation of hypoglycemic effect)
- Local anesthetics containing PABA (antagonism of sulfonamide antibacterial activity)
Curated Content: Needs Vetting Before Put to Clinical Use