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acetarsol

A07AX02

Forms & Strengths

Vaginal inserts/tablets: 250 mg
Topical powder: 5%

Adult Dosing

Vaginitis/Trichomoniasis: 1 insert (250 mg) intravaginally daily for 7-14 days
Amebiasis (historical): 250 mg orally 2-3 times daily for 7-10 days

Pediatric Dosing

Safety and efficacy in pediatric populations not established
Not recommended for use in children due to risk of systemic arsenic toxicity

Indications

Treatment of vaginal infections including Trichomonas vaginalis and candidiasis
Historical use as an antiprotozoal agent for amebiasis

Mechanism of Action

Organoarsenic compound that exerts protozoicidal and anti-infective effects
Inhibits sulfhydryl-containing enzymes in susceptible microorganisms, disrupting metabolic processes

Contraindications

Hypersensitivity to acetarsol or other arsenic compounds
Severe hepatic impairment
Severe renal impairment
Optic neuritis or pre-existing optic nerve damage

Adverse Reactions

Local irritation, burning, or pruritus at the application site
Systemic toxicity (with excessive absorption): optic atrophy, peripheral neuropathy
Gastrointestinal distress (nausea, vomiting, abdominal pain)
Hypersensitivity reactions including rash and dermatitis

Drug Interactions

Concurrent use with other nephrotoxic drugs increases risk of renal injury
Other neurotoxic agents may exacerbate peripheral neuropathy or optic damage
Chelating agents (e.g., dimercaprol) may reduce toxicity in cases of overdose

Curated Content: Needs Vetting Before Put to Clinical Use