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ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › ANTIPROPULSIVES › Antipropulsives
morphine, combinations
A07DA52
Forms & Strengths
- oral tablet: 5mg/325mg
- oral tablet: 10mg/325mg
- oral solution: 5mg/5ml/325mg/5ml
Adult Dosing
- 10-30mg every 4 hours
- initial dose: 5-10mg
- titrate dose to pain relief
Pediatric Dosing
- 0.1-0.2mg/kg/dose
- every 4 hours as needed
- maximum daily dose: 10mg
Indications
- moderate to severe pain
- diarrhea-predominant irritable bowel syndrome
- cough suppression
Mechanism of Action
- mu receptor agonism
- increased gut transit time
- inhibition of gut motility
Contraindications
- hypersensitivity to morphine
- acute bronchial asthma
- intestinal obstruction
Adverse Reactions
- constipation
- somnolence
- vomiting
- respiratory depression
Drug Interactions
- alcohol
- sedatives
- cimetidine
- ritonavir
- ketoconazole
Curated Content: Needs Vetting Before Put to Clinical Use